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FormuMax Scientific F70101C-A代理现货
产品名称 | 产品编号 | 规格 | 储存 | 价格(元) |
Clophosome®-Clodronate Liposomes (Neutral) 中性氯氟松(体内巨噬细胞清除剂) | 40335ES05 | 2ml | 4℃ | 2566.00 |
Clophosome®-Clodronate Liposomes (Neutral) 中性氯氟松(体内巨噬细胞清除剂) | 40335ES10 | 10ml | 4℃ | 8566.00 |
产品描述
Clophosome®(氯氟松)是目前市场上的用于高效巨噬细胞耗竭的氯磷酸二钠脂质体。静脉注射0.2ml Clophosome®-Clodronate Liposomes,24hr后脾脏(红髓巨噬细胞)中巨噬细胞清除率达到80%-90%。Clophosome分子包被在小MLV脂质体胶囊中,具有活性高、稳定性高及使用方便等特点。Clophosome®中装载的氯膦酸二钠是一种特异的杀伤巨噬细胞的药物,可以通过诱导巨噬细胞凋亡来剔除组织中的巨噬细胞。Clophosome®-Clodronate Liposomes在长期保存后仍能保持均匀的、自由流动状态,不粘稠、易于注射。该产品为无菌生产。
Clophosome®-Clodronate Liposomes适用于多种注射方式,如静脉注射、腹腔注射、皮下注射、鼻内注射等。
FormuMax Scientific F70101C-A代理现货
运输与保存方法
产品4℃保存。冰袋运输。不能冻存!使用前一定要充分混匀并恢复到室温。
注意事项
1.为了您的安全和健康,请穿实验服并戴一次性手套操作。
2.使用前一定要充分混匀并恢复到室温。
产品使用
使用前,可使用PBS稀释至工作浓度。
巨噬细胞清除时,推荐起始剂量为0.15-0.2 ml/20-25g动物体重(i.v.或i.p.)。具体剂量需根据实验进一步优化。
注:需要清除巨噬细胞超过一周时:第1天注射200 µL (20-25g体重)。为得到更加*的结果,提前注射2天。为更长时间的清除巨噬细胞,第1次注射 200 µL,每4天注射100 µL。
Clophosome®-A- Clodronate liposomes (Anionic)
Clophosome®-A, negatively-charged Clodronate liposomes, offers superior efficiency of macrophagedepletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stABIlity, and convenience of use. It is formulated to an exceptionally highClodronate/lipid ratio. Free Clodronate is cleaned out and the Liposomal encapsulation efficiency of Clodronateis more than 90%.Clophosome liposomes remain homogenous even after long term storage in fridge. It is not viscous and easy to inject even with fine needles.It is manufactured sterilefor long term shelf-life.
The product is suitable for dosing with various routes includingintravenous, intraperitoneal, subcutaneous, intranasal,intratracheal and etc. We have achieved > 90%depletion in splenicmacrophages (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection.A starting dose of 0.15-2 mL (i.v. or i.p.) for 20-25ganimal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for specific applications.
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